POS0257 TOWARDS A SIMPLIFIED FLUID-SENSITIVE MRI-PROTOCOL IN SMALL JOINTS OF THE HAND IN EARLY ARTHRITIS PATIENTS: RELIABILITY BETWEEN MDIXON AND REGULAR FSE FAT SATURATION MRI-SEQUENCES

Background: MRI facilitates early recognition of rheumatoid arthritis (RA) by depicting inflammation. Contrast-enhanced T1-weighted and T2-weighted fat-suppressed sequences have been sensitive thus recommended, but are hampered invasiveness, costs long scan time. Therefore we introduced a modified Dixon-sequence (mDixon) which is more patient-friendly, reduces cost, times 83%. However, it not known if this mDixon-sequence reliable in relation to regular MRI-sequences with without contrast (T1- T2-weighted, respectively). Objectives: We determined the reliability between respectively) mDixon-MRI patients. Methods: 29 patients underwent fat-suppressed-MRI T2-weighted) mDixon-sequences, metacarpophalangeal-2-5 wrist-joints. Two readers scored erosions, osteitis, synovitis tenosynovitis. Intraclass correlation coefficients (ICCs) readers, comparing two sequences, were studied. Spearman correlations determined. Results: Performance regular-MRI was good excellent (ICCs all ≥0.88). The reader ICC also for ≥0.76). Next, ICCs investigated determine mDixon. total RAMRIS score 0.87 (95%CI 0.74-0.94), erosions 0.88 0.69-0.95), inflammation 0.84 0.69-0.82). individual MRI-inflammation scores, had osteitis 0.97 0.93-0.98), tenosynovitis 0.78 0.58-0.89), 0.57 0.26-0.77). In addition, scores highly correlated RAMRIS, (ρ=0.82, ρ=0.81, ρ=0.80, Conclusion: Regular-MRI perform equally well, suggests that detect joint Thus, first step towards an simplified abridged MRI-protocol small hand-joints ultimate goal will be implementation sequence. Validation larger studies warranted. Disclosure Interests: None declared